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Alison J Butt Selected Research

persin

1/2016Microtubule-stabilizing properties of the avocado-derived toxins (+)-(R)-persin and (+)-(R)-tetrahydropersin in cancer cells and activity of related synthetic analogs.
12/2011Synthesis and in vitro evaluation of analogues of avocado-produced toxin (+)-(R)-persin in human breast cancer cells.
10/2007Synergistic cytotoxicity between tamoxifen and the plant toxin persin in human breast cancer cells is dependent on Bim expression and mediated by modulation of ceramide metabolism.
9/2006A novel plant toxin, persin, with in vivo activity in the mammary gland, induces Bim-dependent apoptosis in human breast cancer cells.

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Alison J Butt Research Topics

Disease

18Breast Neoplasms (Breast Cancer)
01/2016 - 07/2002
7Neoplasms (Cancer)
01/2016 - 08/2003
1Ovarian Neoplasms (Ovarian Cancer)
01/2016
1Carcinoma (Carcinomatosis)
01/2008
1Necrosis
09/2006
1Disease Progression
07/2005
1Infections
08/2003

Drug/Important Bio-Agent (IBA)

5Estrogens (Estrogen)FDA Link
11/2013 - 01/2008
4Estrogen Receptor Modulators (Antiestrogen)IBA
01/2016 - 12/2006
4persinIBA
01/2016 - 09/2006
4TamoxifenFDA LinkGeneric
11/2013 - 10/2007
4Proteins (Proteins, Gene)FDA Link
11/2013 - 07/2005
3Estrogen ReceptorsIBA
01/2016 - 10/2007
3Messenger RNA (mRNA)IBA
01/2008 - 08/2003
3Insulin-Like Growth Factor Binding Protein 3IBA
07/2005 - 07/2002
3Insulin-Like PeptidesIBA
07/2005 - 08/2003
2afimoxifene (hydroxytamoxifen)IBA
01/2016 - 10/2007
2Fulvestrant (Faslodex)FDA Link
09/2011 - 12/2006
2Cyclin D1IBA
01/2008 - 07/2005
2PhytochemicalsIBA
10/2007 - 09/2006
2Insulin-Like Growth Factor Binding Protein 5IBA
07/2005 - 08/2003
2Insulin-Like Growth Factor Binding ProteinsIBA
04/2004 - 08/2003
1Excipients (Suspending Agents)IBA
01/2016
1Pharmaceutical PreparationsIBA
01/2016
1tetrahydropersinIBA
01/2016
1Member 1 Subfamily B ATP Binding Cassette TransporterIBA
01/2016
1mouse brain-derived carcinostatic factor (NBCF)IBA
03/2014
1Phenobarbital (Luminal)FDA Link
11/2013
1Tyrosine (L-Tyrosine)FDA Link
11/2013
1Cytostatic AgentsIBA
12/2011
1Aromatase InhibitorsIBA
09/2011
1CyclinsIBA
01/2008
1Progestins (Progestagens)IBA
01/2008
1Selective Estrogen Receptor Modulators (SERM)IBA
01/2008
1CeramidesIBA
10/2007
1SteroidsIBA
10/2007
1Hormones (Hormone)IBA
10/2007
1Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA
10/2007
1Conjugated Linoleic AcidsIBA
10/2007
1Oncogene Proteins (Oncogene Protein)IBA
12/2006
1Cyclin EIBA
07/2005
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
07/2005
1Caspase 9IBA
07/2005
1Caspase 8 (Caspase-8)IBA
07/2005
1Epidermal Growth Factor (EGF)IBA
04/2004
1Complementary DNA (cDNA)IBA
04/2004
1Growth InhibitorsIBA
08/2003

Therapy/Procedure

7Therapeutics
08/2008 - 04/2004